

Veeam licensing won’t be the only consideration here though, you’ve not made any mention of what storage you’ll be using so I’d like to highlight one of the go to storage systems for VDI: VMware vSAN.

You can then leverage tags to determine what must be backed up. Your Veeam licensing can be done per socket or per instance, I’d recommend per instance due to the amount of redundant data copies within a VMware Horizon environment, you’d be fully featured but it would be cheaper.

It would be difficult to have an official support for it as there are so many varied deployments and that will vary dramatically what can be protected. Unlike some other applications such as Microsoft Exchange, Veeam don’t have official “application support” for VMware Horizon.
